Fri Aug 09 2024

110 articles - From Friday Aug 02 2024 to Friday Aug 09 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastrointest Endosc

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of chronic pancreatitis: summary and recommendations.

For symptomatic pseudocysts, the ASGE suggests endoscopic therapy over surgery. This document clearly outlines the process, analyses, and decision processes used to reach the final recommendations and represents the official ASGE recommendations on the above topics.

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Colonoscopy Quality Measures and Adherence to Follow-up Guidelines Among Endoscopists Participating in a United States Endoscopy Registry.

Additional attention may be needed to achieve more consistent adherence to guidelines for colonoscopy follow-up recommendations.

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Meta-analysis

meta-analyses and systematic reviews

Endoscopy

ENDOLUMINAL RADIOFREQUENCY ABLATION WITH STENTING VS STENTING ONLY IN PATIENTS WITH MALIGNANT BILIARY OBSTRUCTION: A META-ANALYSIS OF RANDOMISED TRIALS.

Combining endoluminal RFA and stenting may improve overall survival in patients with malignant biliary obstruction. RFA did not impact stent patency significantly.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

A personalised algorithm predicting the risk of intravenous corticosteroid failure in acute ulcerative colitis.

These pragmatic personalised risk scores (available at have comparably strong performance characteristics and usability enabling the identification of individuals at high risk of corticosteroid non-response before or after endoscopic assessment. The ROR scores have the potential to challenge conventional acute UC treatment paradigms by identifying patients who may benefit from early rescue therapy or participation in relevant clinical trials.

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Cardiometabolic criteria as predictors and treatment targets of liver-related events and cardiovascular events in metabolic dysfunction-associated steatotic liver disease.

Cardiometabolic criteria can be used as predictors and treatment targets for cardiovascular event risk in MASLD. Developing predictors and therapeutic targets for liver-related events is a future challenge.

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Development of hepatic fibrosis in common variable immunodeficiency-related porto-sinusoidal vascular disorder.

In this CVID cohort, NRH is the most common initial histological finding; however, unexpectedly fibrosis progresses over time in a subgroup of patients. A better understanding of the underlying causal process of liver disease CVID might lead to improved outcomes.

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Impact of HCV eradication on recurrence pattern and long-term outcomes in patients with HCV-related hepatocellular carcinoma undergoing radiofrequency ablation.

HCV eradication was associated with a significant reduction in distant recurrence, mortality and hepatic decompensation following RFA in patients with HCV-related HCC.

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Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS).

There is evidence for the potential role of early maladaptive weight control/eating behaviours in the development of adult IBS among females.

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Non-selective beta-blocker is associated with reduced mortality in critically ill patients with cirrhosis: A real-world study.

Prior use of NSBB is associated with improved 28- and 90-day mortality in critically ill cirrhosis patients with AD which is mediated probably by blunting of the inflammatory response.

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Am J Gastroenterol

Patients With Cirrhosis Rapidly Review Potentially Abnormal Hepatocellular Carcinoma Surveillance Results Through the Patient Portal.

Patients rapidly review imaging results through the portal, often before providers.

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Clin Gastroenterol Hepatol

Biomarkers for prediction of alcohol-related liver cirrhosis- A general population-based Swedish study of 537 250 individuals.

Biomarkers commonly used in primary care settings are highly associated with incident ARLC in the general population. Elevation of these commonly available biomarkers should prompt consideration of further investigation of a possible high level of alcohol consumption.

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Development and Validation of a Noninvasive Model for the Detection of High-Risk Varices in Patients with Unresectable HCC.

A model incorporating clinical and imaging data can accurately predict the absence of high-risk varices in patients with HCC and avoid EGD in many low-risk patients prior to the initiation of systemic therapy, thus expediting their care and avoiding treatment delays.

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Endoscopic, Histologic, and Composite Endpoints in Patients with Ulcerative Colitis Treated with Etrasimod [106/120 characters, including spaces].

Etrasimod was superior to placebo for achievement of stringent histologic and composite endpoints; NCT03945188, NCT03996369.

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LIVE ROTAVIRUS VACCINATION APPEARS LOW-RISK IN INFANTS BORN TO MOTHERS WITH INFLAMMATORY BOWEL DISEASE ON BIOLOGICS.

Immune function testing was normal and administration of live rotavirus vaccination appeared low-risk in biologic-exposed infants irrespective of circulating drug levels.

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Prevalence of Endoscopically Curable Low-Risk Cancer amongst Large (≥20mm) Non-Pedunculated Polyps in the Right Colon.

The proportion of right colon LNPCP referred for ER containing low-risk cancer amenable to endoscopic cure was <1%, in a large, multicentre Western cohort. A universal ESD strategy for the management of right colon LNPCP is unlikely to yield improved patient outcomes given the minimal impact on oncological outcomes. Clinical trial Australian Colonic Endoscopic Resection (ACE) cohort NCT01368289 ( /ct2/show/NCT01368289); NCT02000141 ( /ct2/show/NCT02000141).

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Tenofovir is associated with a better prognosis than entecavir for hepatitis B virus-related hepatocellular carcinoma.

Among patients with HBV-related HCC, those treated with tenofovir had a better prognosis than those treated with entecavir, particularly among those with prolonged survival.

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Endoscopy

Predicting ERCP procedure time - the SWedish Estimation of ERCP Time (SWEET) tool.

Based on new insights into the factors affecting ERCP time, we created the SWEET tool, the first specific tool for preintervention estimation of ERCP time, which is easy-to-apply in everyday clinical practice, to guide efficient ERCP scheduling.

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Gastroenterology

An Empirical Dietary Pattern Associated with the Gut Microbial Features in Relation to Colorectal Cancer Risk.

CMDS was associated with increased CRC risk, especially for tumors with detectable F. nucleatum, pks + E. coli, and ETBF in tissue. Our findings support a potential role of the gut microbiome underlying the dietary effects on CRC.

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Atlas of metastatic gastric cancer links ferroptosis to disease progression and immunotherapy response.

This study represents the largest single-cell dataset of metastatic GACs to date. High-resolution mapping of the molecular and cellular dynamics of GAC metastasis has revealed a rationale for targeting ferroptosis defense in combination with CAR T-cell therapy as a novel therapeutic strategy with potential immense clinical implications.

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Gastrointest Endosc

Feasibility of a new endoscopic suturing device: a first Western experience.

EHS was technically feasible and applicable in different anatomical locations. Further studies may elucidate a possible effect on complication rates of endoscopic resections.

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Glucagon-like Peptide-1 Receptor Agonists and Capsule Endoscopy in Patients with Diabetes: A Matched Cohort Study.

GLP-1 RA usage is associated with prolonged gastric transit time and a higher rate of incomplete small bowel evaluation during VCE. Future studies may be crucial for evaluating strategies to mitigate these effects.

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Prospective, multicenter, self-controlled clinical trial on the effectiveness and safety of cable-transmission magnetically controlled capsule endoscope system for the examination of upper gastrointestinal diseases.

The diagnostic performance of CT-MCCE is comparable to that of EGD in the completion of upper GI tract examinations and lesion detection. Furthermore, the improved tolerance of CT-MCCE in detecting upper GI diseases was noted without any observed adverse events.

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Gut

Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease.

Statin usage was associated with a relatively lower long-term risk of all-cause mortality, LREs and liver stiffness progression in patients with MASLD.

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Prevalence of steatotic liver disease, advanced fibrosis and cirrhosis among community-dwelling overweight and obese individuals in the USA.

Using advanced MRI methods among community-dwelling overweight and obese adults, the prevalence of cirrhosis was 4.5%. Most common SLD subcategory was MASLD with 67% of individuals, whereas MetALD and ALD were less common. Systematic screening for advanced fibrosis among overweight/obese adults may be considered.

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Hepatology

Association between longitudinal biomarkers and major adverse liver outcomes in patients with non-cirrhotic metabolic dysfunction-associated steatotic liver disease.

In addition to baseline measurements of non-invasive biomarkers such as FIB-4 and AST, and platelets taken at MASLD diagnosis, monitoring their values over time is important, as the latest value of these biomarkers is closely associated with the risk of future MALO. The rate of change may not be as important.

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Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study.

Adherence to the EAT-Lancet reference diet was inversely associated with risk of MASLD as well as its severity.

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Drug induced cholestatic liver diseases.

Furthermore, the review provides an overview on the risk factors, genetic determinants and the pathophysiology of hepatobiliary transporters leading to cholestasis. Management, areas of uncertainty and future direction are also presented.

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J Hepatol

Outcomes in the Asian subgroup of the phase III randomised HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma.

STRIDE improved outcomes vs sorafenib in the Asian subgroup. These results support the benefits of STRIDE for participants with uHCC globally, including the Asia-Pacific region. Clinical trial number NCT03298451 IMPACT AND IMPLICATIONS The global, phase III HIMALAYA study found that the STRIDE (Single Tremelimumab Regular Interval Durvalumab) regimen improved overall survival (OS), including long-term OS, vs sorafenib, and that durvalumab monotherapy was noninferior to sorafenib in participants with unresectable hepatocellular carcinoma (uHCC). However, there are differences in the aetiology and clinical practices related to HCC in parts of Asia, compared to Western countries and Japan, which could lead to differences in treatment outcomes between these regions. The results of this analysis demonstrate the benefits of STRIDE for participants in the Asia-Pacific region, consistent with the full, global study population. Overall, these findings continue to support the use of STRIDE in a diverse population, reflective of uHCC globally.

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PegIFN alpha-2a reduces relapse in HBeAg-negative patients after nucleo(s)tide analogue cessation: A randomized-controlled trial.

Switching from NUC to PegIFN-α-2a treatment for 48 weeks significantly reduces virological relapse rates and achieves higher HBsAg loss rates than NUC treatment cessation alone in HBeAg-negative chronic hepatitis B patients. Impact and implications Nucleo(s)tide analogue (NUC) cessation can lead to HBsAg clearance but also a high rate of virological relapse, but an optimised scheme to reduce the virological relapse rate after NUC withdrawal is yet to be reported. This randomized controlled trial investigated the effect of switching from NUC to PegIFN-α-2a treatment for 48 weeks on virological relapse until week 96 in HBeAg-negative chronic hepatitis B patients. The interferon monotherapy group had a significantly lower cumulative virological relapse rate (20.8% vs 53.6%, P < 0.0001) and higher HBsAg loss rate (21.5% vs 9.0%, P= 0.03) than the NUC cessation group until week 96. This provides an optimized strategy for NUC cessation in HBeAg-negative patients.

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Transposon-based oncogene integration in Abcb4(Mdr2)-/- mice recapitulates high susceptibility to cholangiocarcinoma in primary sclerosing cholangitis.

Mdr2-/-, which features reliable tumor induction in PSC-like background of biliary injury and fibrosis. Global gene expression alterations were identified and standardized tools, including automated whole slide image analysis methodology for tumor burden and feature analysis, were established to enable systematic research into PSC-CCA biology and formal pre-clinical drug testing.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: The future of managing drug induced liver injury.

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Editorial: Tracking the course of Wilson's disease.

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Clin Gastroenterol Hepatol

Genetics of MASLD: The State of Art Update.

A special chapter is dedicated to gene-based therapeutics. The limitations of approved pharmacological approaches are discussed, and the potential of gene-related mechanisms in therapeutic development is reviewed, including the decision to perform genetic testing in patients with MASLD.

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Endoscopy

Which is cheaper: a fully covered metallic stent or a choledochoscope?

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Gastroenterology

Everything you wanted to know about pancreatic ducts but didn't know where to look.

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Gastrointest Endosc

Topical Hemostatic Preventative and Therapeutic Agents: Clinical Impact and Utility.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Calendar of Courses, Symposiums and Conferences.

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External Submucosal Dissection of an Anal Canal Polyp.

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Gastric Motility Assays May Not Capture the Entire Clinical Picture in Patients Using Glucagon-Like Peptide-1 Receptor Agonists.

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Mahvash disease: an uncommon condition in a young female patient.

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Submucosal Lifting Agents: An Updated Review.

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Clin Gastroenterol Hepatol

Baseline and dynamic MAF-5 score to predict liver fibrosis and liver-related events in general population with MASLD.

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Double Wire Cannulation and Mechanical Lithotripsy in Billroth II with Therapeutic Gastroscope.

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Trainee participation and outcomes in high-risk ERCP: a secondary analysis of the Stent versus Indomethacin trial.

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Endoscopy

Antral early gastric neoplasm with severe oral scarring successfully treated by endoscopic submucosal dissection using retroflex approach and a novel, thin therapeutic endoscope.

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Balloon catheter-assisted rescue for misplacement of lumen-apposing stent across the pylorus in endoscopic ultrasound-guided transduodenal drainage of walled-off necrosis.

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Combined endoscopic drainage for afferent loop obstruction and bilioenteric anastomosis stricture in a patient after pancreatoduodenectomy.

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Continuous low water pressure dissection technique minimizing air bubbles during underwater endoscopic submucosal dissection.

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Electrohydraulic lithotripsy: a safe and effective technique to retrieve an impacted Dormia basket.

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Endoscopic direct therapy for appendicitis and diverticulitis in one patient with right-sided abdominal pain.

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Endoscopic ultrasound-guided hepaticojejunostomy for complete biliary anastomotic stricture: the echo-free space technique for scope insertion in surgically altered anatomy.

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Endoscopic vacuum therapy of a refractory esophagopleural fistula in a patient with Boerhaave syndrome, using an innovative hybrid stent.

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Gel immersion endoscopy for evaluation of a gastric submucosal tumor during endoscopic ultrasound-guided fine-needle aspiration.

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Interpreting studies comparing lumen-apposing metal stents and plastic stents for walled-off necrosis: wisdom is the need of the hour.

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Lumen-apposing metal stent-induced perforation during endoscopic ultrasound-directed transgastric retrograde cholangiopancreaticography managed with an endoscopic suturing device.

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Mantis-like claw clip as a rescue therapy for the closure of an unexpected cricopharyngeal mucosal tear during peroral endoscopic myotomy.

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Multiple pancreaticobiliary fistulas combined with acute necrotizing pancreatitis: a rare complication of pancreatic extracorporeal shock wave lithotripsy.

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Novel thin endoscope enables endoscopic submucosal dissection without retroflexion for tumor involving the whole pyloric ring.

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One-step primary endoscopic ultrasound-guided choledochoduodenostomy without lumen-apposing metal stent using a Franseen needle and an ultra-stiff high-sliding guidewire.

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Percutaneous transhepatic cholangioscopy combined with endoscopic retrograde cholangiopancreatography for bilateral biliary bridge drainage for malignant biliary obstruction.

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Rectal endoscopic full-thickness resection of peritoneal loose body.

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Refractory gastrocutaneous fistula after gastrostomy removal successfully treated with submucosal dissection and endoscopic suture.

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Removal of obstructed pancreatic stent tube and biliary stones in patient with Roux-en-Y anatomy under direct endoscopic view.

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Rescue endoscopic treatment with completion by radical surgery following misplacement of a partially covered metal stent in an anastomotic fistula post-Lewis Santy esophagectomy.

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Successful observation of intraductal papillary mucinous neoplasm in the accessory pancreatic duct using a novel peroral pancreatoscopy.

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Transluminal opening technique for multiple septa in liver abscess using novel cholangioscope.

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Underwater endoscopic mucosal resection for circumferential adenoma of the ileocecal valve.

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Will computer-aided detection of polyps decrease colorectal cancer incidence and mortality?

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Gastroenterology

A MERFISHing expedition for colitis.

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A Rare Cause of Blood in Stool and Anemia.

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A concerning case of severe gastritis with gastrointestinal protein loss.

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Building Your Professional Brand-Tips for Early Career Faculty.

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High pathological response rate after neoadjuvant immunotherapy in locally advanced mismatch repair-deficient colon cancer (NICHE-2 study).

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Longitudinal gut microbiome shifts correlate with clinical outcomes of immune checkpoint inhibitors-treated melanoma: time for microbial biomarkers in oncology?

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Minimal Incremental Benefits of Computer-aided Optical Diagnosis of Colorectal Polyp Histology in a Large Prospective Cohort.

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Rethinking the Gastroenterology Morbidity and Mortality Conference: Insights from a Scoping Review.

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The Search for the Ideal Weight Loss Drug: Targeting NTS-GLP1R Neurons for Satiety Without Aversion.

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The evolving story of Blastocystis: from foe to friend.

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Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness.

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What are the causes of acute pancreatitis?

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Gastrointest Endosc

An unusual case of non-classifiable motor dysphagia, rescue by endoscopic ultrasound and myotomy.

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An unusual type of duodenal polyp.

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Appendiceal cast due to fecal impaction in the appendix.

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Concomitant peroral endoscopic myotomy and gastric peroral endoscopic myotomy for persistent dysphagia and iatrogenic gastroparesis after laparoscopic fundoplication.

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Gallbladder Perforation During Endoscopic Internalization of Percutaneous Cholecystostomy Tube: Lessons Learned.

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Submucosal Glands during Endoscopic Submucosal Dissection of Esophageal Adenocarcinoma.

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Top Tips: EUS-Guided Portal Pressure Gradient Measurement.

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Gut

Animal experiments of a new through-the-scope full-thickness endoscopic suturing device.

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Endocytoscopy with automated multispectral intestinal barrier pathology imaging for assessment of deep healing to predict outcomes in ulcerative colitis.

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FTO/m6A/GPNMB axis: a novel promising target for hepatocellular carcinoma (HCC) treatment?

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Risk of developing IBD in high-risk individuals: the need to study the exposome more.

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Submucosal steroid pre-injection strategy to prevent oesophageal stricture after circumferential endoscopic submucosal dissection.

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Hepatology

Back to phosphodiesterase inhibitors for liver disease: are we ready for clinical trials?

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Comparative performance of methylation DNA markers, brushing cytology, and FISH in diagnosing malignant biliary strictures.

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Do autoantigens drive MASH progression?

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Letter to the Editor: Molecular classification based on multi-omics facilitates prognostic stratification and personalized treatment in hepatocellular carcinoma.

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Letter to the editor: Bridging the gap between hepatitis C virus diagnosis and treatment to achieve elimination in the united states.

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Management of patients with advanced hepatocellular carcinoma receiving atezolizumab/bevacizumab: Take care of cirrhosis!

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Reply: Don't forget to discuss TIPS in patients surviving an episode of alcoholic hepatitis.

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Spatially-resolved immune drivers of HBV-associated HCC relapse.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Tracking the course of Wilson's disease: Authors' reply.

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Letter: Light in the lumen-The expanding role of intestinal ultrasound for functional symptoms in inflammatory bowel disease.

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Letter: Light in the lumen-The expanding role of intestinal ultrasound for functional symptoms in inflammatory bowel disease. Authors' reply.

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Clin Gastroenterol Hepatol

Letter to the Editor Regarding Long-Term Proton Pump Inhibitor Use: Review of Indications and Special Considerations.

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Gut

Dynamics of the gut microbiome in FAP patients undergoing intensive endoscopic reduction of polyp burden.

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J Hepatol

Addressing Bias and Improving Research on Gender and Racial Disparities in Hepatitis B Assessment and Treatment.

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Bulevirtide monotherapy in patients with chronic HDV needs further evaluation.

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Normothermic liver machine perfusion as a dynamic platform for assessment and treatment of organs from a donor with Malaria - expending the indications.

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Obtaining first-line induction in autoimmune hepatitis: aren't we underestimating prednisolone?

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The Potential of Machine Learning to Predict Early Allograft Dysfunction after Normothermic Machine Perfusion in Liver transplantation.

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